What Diet Pills Do Doctors Prescribe – The examples and perspectives in this article relate primarily to the United States and do not reflect a worldwide view of the subject. You can promote this article; You can discuss the issue on the talk page; Or you can create a new article as appropriate. (September 2020) (Learn how to remove this template message)
Orlistat (Xical); sibutramine (Meridia), the most commonly used drug to treat obesity, has been withdrawn directly because of cardiovascular side effects;
What Diet Pills Do Doctors Prescribe
Anti-obesity drugs or weight-loss drugs are pharmacological agents that help reduce or maintain weight. These drugs alter the basic processes of the human body by altering appetite or caloric absorption. Changes in weight control.
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The main treatments for overweight and obesity are diet (a healthy diet and calorie restriction) and exercise.
In the United States, Orlistat (Xical) and Semaglutide (Wegovy) have been approved by the FDA for long-term use.
Xical reduces intestinal fat absorption by inhibiting pancreatic lipase. Wegovy is a class of drugs that has shown promise as a relatively fair and effective anti-obesity measure.
Because of the potential side effects and limited evidence of small weight loss protocols in children and adolescents with obesity;
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It is recommended to prescribe anti-obesity drugs only if the benefits of treatment are expected to outweigh its risks.
In the United States, The Food and Drug Administration says that those with a body mass index of at least 30 or a body mass index of at least 27 represent a patient population with at least one type of weight-related disease. To justify the use of anti-obesity drugs.
Although anorectics are primarily intended to suppress appetite, many drugs in this class also act as stimulants (eg, amphetamines), and patients abuse “off-label” drugs to suppress appetite (eg, digoxin).
The first reported attempts at weight loss were by the Greek physician Soranus of Ephesus in the second century AD. In addition to laxatives and purgatives, he used heat, Massage It has remained a mainstream treatment for over a thousand years. It wasn’t until the 1920s and 1930s that new treatments began to emerge. Based on its effectiveness for hypothyroidism, thyroid hormone has become a popular treatment for obesity in euthyroid individuals. It has a minimal effect but can cause symptoms of hyperthyroidism as side effects such as palpitations and difficulty sleeping. 2, 4-Dinitrophol (DNP) was introduced in 1933. It did this by removing the metabolic process of oxidative phosphorylation in the mitochondria and making them release heat instead of ATP. The most noticeable side effect is a feeling of warmth with frequent sweating. Although overdose is rare, An increase in body temperature eventually leads to hypothermia. In 1938, DNP is no longer used because the FDA has the power to pressure manufacturers who voluntarily withdraw from the market.
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Amphetamine (marketed as Bzedrine) became popular for weight loss in the late 1930s. They work primarily by reducing appetite and have other beneficial effects such as increasing alertness. Amphetamine use increased over the next decade, including Obetrol, culminating in the “rainbow pill” regimen.
It is a combination of several pills that will help you lose weight throughout the day. Common medications include stimulants such as amphetamines; thyroid hormones; diuretics, digital tablets, Barbiturates are often included to counteract the side effects of laxatives and stimulants.
In 1967/1968, Several deaths from diet pills led to state investigations and the gradual implementation of more restrictions on the market.
Although rainbow pills were banned in the US in the late 1960s, They were rediscovered in South America and Europe in the 1980s.
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Rainbow diet pills were reintroduced in the US in the 2000s, with subsequent adverse health effects.
At the same time, Phtermine was approved by the FDA in 1959, and fluramine was approved in 1973. They did not become more popular than other drugs until 1992, when a researcher reported a 10% weight loss that was maintained for over 2 years.
F-ph was born and quickly became the most widely used dietary supplement. Dexfluramine (Redux) was developed in the mid-1990s as an alternative to fluramine with fewer side effects and received regulatory approval in 1996. However, That combination coincides with increasing evidence that up to 30% of the valve can cause heart disease. In September 1997, F-ph and dexfluramine were withdrawn from the market.
Ephedra was pulled from the US market in 2004 because it raises blood pressure and can lead to stroke and death.
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Some sufferers find that diet and exercise are not a viable option. For these patients, anti-obesity drugs are a last resort. In the United States, Semaglutide (Wegovy) is FDA approved for the management of chronic weight loss.
Other weight-loss drugs are stimulants that are recommended for short-term use and are of limited use for critically ill patients who may need to lose weight over months or years.
In 2021, a review concluded that “intestinal peptide analogs such as semaglutide […] and […] tirzepatide are currently the most advanced in clinical development.”
Further analysis in 2022 found these two peptides to be “the most promising candidates for the next battle in the anti-obesity market.”
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An article in The New York Times noted the high costs of semaglutide and tirzepatide and suggested that “many people who would do best from weight loss cannot afford such expensive drugs.”
In June 2021, The US Food and Drug Administration (FDA) has approved Semaglutide injection, sold under the brand name Wegovy, for long-term weight management in adults.
Wegovy was approved for medical use (“used in conjunction with diet and physical activity”) in the European Union in January 2022.
In particular, Phase 3 clinical trials found that patients lost an average of 16% of their initial body weight after 71 weeks.
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He was diagnosed with type 2 diabetes (though not particularly weight loss) under the name Mounjaro, May 13. Confirmed in 2022.
Exatide (Byetta) is a long-acting analog of the GLP-1 hormone released in the intestines in response to food stress. Among other effects, GLP-1 delays gastric emptying and promotes postprandial satiety. Some obese people are deficient in GLP-1, and diet further reduces GLP-1.
Byetta is currently available as a treatment for type 2 diabetes. Some patients experience significant weight loss when taking Byetta. Disadvantages of Byetta include the fact that it must be injected subcutaneously twice a day and that it can cause severe nausea and vomiting in some patients, especially when starting therapy. Byetta is only recommended for patients with type 2 diabetes.
Orlistat (Xical) reduces intestinal fat absorption by inhibiting the pancreatic lipase enzyme. Frequent steatorrhea of the fatty intestine is a side effect of using Orlistat. But if the fat is reduced, the symptoms will often be relieved. Originally available by prescription only, it was approved by the FDA for over-the-counter sales in February 2007.
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On May 26, 2010, the United States; The Food and Drug Administration (FDA) has approved a revised label for Xical that includes new safety information about serious liver damage that has been rarely reported with this drug.
Cetilistat is a drug developed to treat obesity. It works similarly to the older drug Orlistat by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the stomach. Without this enzyme, Dietary triglycerides are prevented from being hydrolyzed into absorbable free fatty acids and excreted undigested.
Lorcaserin (Belviq) for obesity with other comorbidities June 28; Approved in 2012. On average, study participants lost weight;
It reduces appetite by activating a type of serotonin receptor called the 5-HT2C receptor in a region of the brain called the hypothalamus known to control appetite.
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This drug has now been withdrawn from the market because a clinical safety trial showed an increased incidence of cancer.
Sibutramine (Meridia), which works in the brain by inhibiting the breakdown of neurotransmitters, reducing appetite and cardiovascular problems, was withdrawn from the market in the US and Canada in October 2010.
Sibutramine increases blood pressure, dry mouth, Constipation It can cause headaches and insomnia and, less commonly, stroke or heart attack, which can sometimes be fatal.
Previously, the US noted that Meridia was a safe drug to fight obesity. The U.S. District Court for the Northern District of Ohio has dismissed 113 lawsuits alleging the drug’s adverse effects, saying clitorises lacked supporting information and the claims involved were ineligible.
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The anorectic antiobesity drug, first approved in Europe in 2006, was withdrawn worldwide in 2008 due to serious psychiatric side effects. It was never approved in the United States.
It works by specifically blocking the docannabinoid system. It was developed from the knowledge that marijuana smokers, often referred to as “wells,” often suffer from hangovers.
Rimonabant is an inverse agonist.
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