Ketogenic Diet Cancer Success Stories – New research shows that fat can prolong life, but some patients are hitting the fat to prevent cancer. Is this smart?
The high-fat/low-carb keto diet is very popular. But is it safe for cancer patients? Image by Getty Images
Ketogenic Diet Cancer Success Stories
Should the keto vegan diet be thrown away as people suggest? Should we try to keep it mostly low and “good” – some olive oil, some fish and the occasional avocado?
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Fat, protein and carbohydrates are the three main players that fuel the human machine and provide almost 100% of our body’s energy. For decades, scientists have been pushing celebrities to come up with the best combination of the two for health and longevity. People are also looking for a big answer to coronary heart disease, diabetes, cancer, and everything else, trying to identify this nutritional silver bullet.
Pathologists (aka epidemiologists) at the Fred Hutchinson Cancer Research Center have been studying fat and dietary health for more than 30 years. Clinical researchers here are also investigating how diet and nutrition can affect cancer treatment and disease recurrence.
What do they say about its benefits and harms, especially in the field of cancer? Here’s your big fat update.
New health findings from a long-term trial of dietary changes by the Women’s Health Initiative specifically addressing fat and women’s health. At the start of the study in 1993, the participants were healthy and disease-free and aged 50 to 79 years. Data were collected through biological samples as well as self-reports.
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The study, led by Dr Ross Printhatch and WHI researchers from across the country and published last month in the journal Nutrition, followed 50,000 women over nearly 20,000 years to see if reducing dietary fat could reduce this risk. to be or not Breast and colon cancer and heart disease.
Almost half of the participants reduced their fat intake to less than 20 percent of total calories and ate more fruits, vegetables, and whole grains than meat, cheese, nuts, and other fat sources. Other participants had a “normal diet” with 35 percent of their calories coming from fat.
Their findings: Women who kept fat low and increased their intake of vegetables, fruits and whole grains lived longer and healthier lives — or at least were less likely to die from breast cancer, reduce the progression of diabetes and prevent coronary heart disease. Women who eat normal and fatty foods.
Fat first came into focus about 60 years ago, when Americans were getting fatter and sicker. Experts conclude that dietary fat must cause obesity and diseases such as diabetes, cardiovascular disease and even cancer. Suddenly, fat was bad and carbs were the best option to break up our great love affair. Sausage and eggs have given way to breakfast cereals – many of which are loaded with sugar. Burgers and steaks have been overtaken by pizza, grills and wraps—many of them processed.
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Dietary Fat: From Enemy to Friend? This fat in the carbohydrate explains the origin of the shock. A review of nutritional science was published late last year. Focusing on fat “carbohydrates—all carbohydrates, including those from grains and highly refined sugars—are harmless and likely prevent weight loss, cancer, and cardiovascular disease through multiple mechanisms,” they wrote. ».
Most foods are a mixture of macronutrients, proteins, and carbohydrates. Apples are primarily carbohydrates, but they also contain protein and fat. Avocado is mainly fat and carbohydrates, but it also contains protein. Meat is usually protein and fat and has little or no carbohydrates. The USDA Dietary Guidelines recommend “recommended amounts of a variety of nutrient-dense foods from all food groups.” Nutrient-rich foods include whole vegetables, fruits, whole grains, seafood, eggs, beans and peas, unsalted nuts and seeds, fat-free and low-fat dairy products, and lean meat and poultry.
As diets shift from high-fat to high-carbohydrate, rates of obesity and diabetes continue to rise while life expectancy declines. Therefore, the friction of macro elements and research has flourished. With back fat and the wildly popular keto (short for ketogenic) diet, it’s bigger than ever.
Fat is the main component of keto – 70% to 80% of total calories, 10% to 20% of protein, and 5% to 10% of carbohydrates. Cutting carbs dramatically forces your body to use another (and potentially harmful) chemical process called ketosis for energy. Glucose (sugar) from carbohydrates becomes a secondary source of fat when the body’s primary fuel is not available. Especially fat deposits in the body (mostly located in the back).
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As a result, you will lose weight. As a result, there are now books, blogs, YouTube channels, Twitter testimonials, and confusion, confusion, and questionable advice from thousands of keto diet experts and new diet enthusiasts. For example, there is actually a bacon and butter keto restaurant. (Read the link between processed meat and cancer.)
Cancer patients love keto, even if it’s not about fitting into tight jeans, but about missing a relapse or progression. And there are many keto cancer resources online. What is missing is a lot of clinical data.
There are many keto diet cancer trials underway in research centers from Florida to Frankfurt. But some are still recruiting, others are closed and many are yet to announce their results. So, some patients DIY it, keto during chemotherapy or other protocols that have no evidence of shrinking or enlarging their cancer.
Others are turning to keto instead of standard treatments—and recommending their peers do the same.
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Carol Oxford Tatum, a 55-year-old research scientist and breast cancer patient in Vacaville, Calif., worries that patients are hurting themselves by taking things too quickly.
“All the papers I’ve read about keto and cancer are in mice,” he says. They are all still mice. We are not mice, there is no clinical evidence that it is healthy.
Breast cancer patients Mia Spano-Curtis (left) and Carol Oxford Tatum Photo by Mia Spano-Curtis and Carol Oxford Tatum.
Tatum has reasons to try it—”the idea of Warburg’s work is to feed cancer on sugar”—but she thinks people often take diet for granted.
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“The whole idea that sugar feeds cancer, yes, sugar feeds us, it feeds all cells,” he said. It has been proven that eating a balanced diet is the healthiest.
Randomized clinical trials — in humans, not mice — are what we should be asking if they exist, Tatum said. Until then, ketotherapy “promotes false hope and causes harm.”
Some of the answers are surprising. Dr. Siddhartha Mukherjee, an oncologist at Columbia University and author of The Emperor of All Diseases, has been researching the ketogenic diet as a potential cancer treatment tool for several years. Among other things, he found that eating keto actually accelerated leukemia.
Specifically, we found little effect of keto on cancer. It actually accelerated AML. But inhibition of keto plus P3 kinase is synergistic. Note: Do not try keto alone outside of a clinical trial.
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But Mukherjee’s August 2018 paper in Nature showed that the ketogenic diet was beneficial, even “synergistic,” with another type of cancer and some treatments. At least in mice.
Dr. W. Gaddy, Fred Hatch, and his clinical colleague are clinical investigators and breast cancer oncologists with the Seattle Cancer Care Alliance.
This pathway regulates cell cycle and proliferation. If it changes and is stressed, the body will start to produce cancer cells of its own accord. Fortunately, there are kinase inhibitors that can turn the pathway’s “on” switch “off.” A cardio diet helps maintain sensitivity to the inhibitor, Geddy says. But—and this is a big dietary but—it only works for those with PIK3 mutations who use this particular kinase inhibitor.
“This is a great example of how the keto diet is actually what you want to pair with this drug,” he said. That’s what preliminary data shows. But it’s really complicated.”
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There is much more to learn. For example, the common diabetes drug metformin also appears to have antitumor effects. “It’s probably a chemical version of keto,” Gaddy said.
The doctor. V.K. Geddy spoke about keto and cancer at the 4th Annual Northwest Breast Cancer Conference in Seattle last month. Video by Komen Puget Sound
“I never go out on a limb, and keto doesn’t cure anything,” says Mia Spano-Curtis, 53, a breast cancer patient advocate from Scotland, Arizona. But she eats “close to keto,” because fattening up and cutting carbs “makes my body more efficient.”
Spano-Curtis says she eats mostly meat, organic fruits and vegetables, beans, fresh cheese, and even the occasional cookie. “Gluten-free in the kitchen,” she says. “Cookies don’t come from a box. I don’t think sugar is friendly to our body.
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Dr. Mario Kratz, Mutual Public Health Researcher
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