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Generic Prescription Diet Pills – The examples and perspectives in this article relate primarily to the United States and do not reflect a global perspective. You can improve this article by discussing the issue on the talk page or creating a new article as needed. (September 2020) (Learn how and who to remove this template message)

Orlistat (Xical), a drug commonly used to treat obesity, and sibutramine (Meridia), have been withdrawn due to cardiovascular side effects.

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Anti-obesity drugs or weight loss drugs are pharmacological agents used to reduce or control weight. These drugs regulate the body’s basic functions, by changing weight, appetite or caloric absorption.

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Diet (healthy eating and calorie restriction) and exercise are the mainstays of treatment for overweight and obese people.

In the United States, orlistat (Xical) and semaglutide (Vegovy) are currently approved by the FDA for long-term use.

Cycal inhibits pancreatic lipase, reducing intestinal fat absorption; Vigo, a GLP-1 analog, is a relatively safe and promising class of drugs as an effective anti-obesity measure.

Limited evidence for potential side effects and weight loss in obese children and adolescents.

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Anti-obesity drugs are only prescribed for obesity where the benefits of treatment are expected to outweigh the risks.

In the United States, the Food and Drug Administration recommends that people with a BMI of at least 30 or a Body Mass Index (BMI) of at least 27 be considered overweight or obese. High health risk to justify the use of anti-obesity drugs.

Anorectics are primarily intended to suppress appetite, but many drugs in this class also act as stimulants (eg, amphetamines), and patients use drugs to suppress appetite (eg, digoxin).

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The first reported attempt is by the Greek physician Soranus of Ephesus in the second century AD. He prescribed elixirs of laxatives and purgatives, as well as heat, massage and exercise. It has been the mainstay of healing for over a thousand years. In the 1920s and 1930s, new agreements were made. Based on its effectiveness for hypothyroidism, thyroid hormone has become a popular treatment for obese people. It was mildly effective, but caused symptoms of hyperthyroidism as well as side effects such as flushing and difficulty sleeping. 2, 4-Dinitrophol (DNP) was introduced in 1933; By stimulating the biological process of oxidative phosphorylation in mitochondria, they produce heat instead of ATP. The most effective part was the elimination of heat by frequent sweating. Overdose, although rare, results in elevated body temperature and potentially fatal hyperthermia. By 1938, DNP had fallen out of use as the FDA gained the power to pressure manufacturers to voluntarily withdraw it from the market.

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Amphetamines (sold as Bzedrine) became popular for abuse in the late 1930s. They first worked by suppressing appetite and had other side effects such as increased alertness. The use of amphetamines, such as obitrol, has increased over the decades and has been dubbed the “diet pill of the world”.

It was a combination of several pills, all of which should help with daytime fatigue. Common regimens include amphetamines, as well as thyroid hormones, diuretics, digitalis, laxatives, and barbiturates to counteract the side effects of stimulants.

A large number of diet pill deaths in 1967/1968 led to the gradual introduction of major restrictions on Sate research and marketing.

Although prescription diet pills were banned in the United States in the late 1960s, they appeared in South America and Europe in the 1980s.

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Prescription diet pills were reintroduced in the United States in the 2000s and brought additional negative health effects.

In addition, phentermine was approved by the FDA in 1959 and fluramine in 1973. Neither drug was more popular than the other, until 1992 when a researcher reported that combining the two led to a 10 percent weight loss that lasted more than two years.

F-ph was born and quickly became one of the most prescribed diet pills. Dexfluramine (Redux) was developed in the mid-1990s as a less harmful alternative to fluramine and received regulatory approval in 1996. However, this coincides with evidence that the combination can cause up to 30 percent of coronary heart disease. As a result, F-ph and dexfluramine were withdrawn from the market in September 1997.

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Ephedra was pulled from the US market in 2004 due to concerns that it could raise blood pressure and cause stroke and death.

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Some parents believe that diet and exercise are not viable options; For these patients, anti-obesity drugs may be a last resort. In the United States, semaglutide (Vegovy) is FDA-approved for chronic weight management.

Some other prescription weight loss medications are stimulants, prescribed for short-term use only, and thus are of limited benefit to obese patients who may need to lose weight over months or years.

A 2021 review concluded that “Intestinal peptide analogs such as semaglutide […] and […] tirezapatide are at the forefront of clinical development.”

Another review in 2022 found that these two peptides are “the most promising candidates for the fight against obesity in the market.”

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An article in the New York Times noted that the cost of semaglutide and tirzapotide is high, and that “people who could benefit greatly from addiction may not be able to afford such broad-spectrum drugs.”

In June 2021, the US Food and Drug Administration (FDA) approved Semaglutide injection, sold under the brand name Wegovi, for long-term weight management in adults.

Vigo was approved for medical use (“used in conjunction with diet and exercise”) in the European Union in January 2022.

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Specifically, the Phase 3 clinical trial found that patients lost 71% of their initial body weight after 16 weeks.

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On May 13, 2022, type 2 diabetes was confirmed (although not specifically for asthma) under the name Mounjaro.

Exatide (Byetta) is a long-acting analog of the hormone GLP-1, which is secreted by the pancreas in response to the presence of food. Among other effects, GLP-1 delays gastric emptying and promotes the feeling of fullness after a meal. Some obese people have a deficiency of GLP-1, and diet can further reduce GLP-1.

Byetta is now available to treat type 2 diabetes. Disadvantages of Byetta include that it must be given by subcutaneous injection twice daily and that in some patients, especially when starting treatment. Byetta is only recommended for type 2 diabetes patients.

Orlistat (Xical) reduces intestinal fat absorption by inhibiting pancreatic lipase. Frequent bowel movements and diarrhea are possible side effects of Orlistat use. But if the fat in the diet is reduced, the symptoms will improve. Originally available only by prescription, it was approved by the FDA for over-the-counter sales in February 2007.

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On May 26, 2010, the US Food and Drug Administration (FDA) approved a revised label for Xical that included new safety information about rare cases of severe liver injury associated with drug use.

Cetilistat is a drug designed to treat obesity. Zyme, which breaks down triglycerides in the gut, works in the same way as the older drug Orlistat by inhibiting pancreatic lipase. Without this enzyme, dietary triglycerides are prevented from being hydrolyzed to absorbable free fatty acids and excreted.

Lorcaserin (Belvic) was approved on June 28, 2012 for obesity and other conditions. The average weight of study participants was lower.

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It reduces anxiety by activating a type of serotonin receptor called the 5-HT2C receptor in an area of ​​the brain called the hypothalamus.

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The drug has now been withdrawn from the market due to an increased incidence of cancer in safety clinical trials.

Sibutramine (Meridia), which works in the brain to prevent deactivation of neurotransmitters and thus heart failure, was withdrawn from the US and Canadian markets in October 2010.

Sibutramine can increase blood pressure, cause dry mouth, constipation, headache, and insomnia, and rarely lead to stroke or heart attack, and sometimes death.

In the past, Meridia was approved by the United States as a safe drug for the treatment of obesity. The U.S. District Court for the Northern District of Ohio has dismissed 113 lawsuits alleging adverse effects of the drug, saying the claims lacked supporting facts and the attorneys involved in the cases lacked competency.

What Is Phentermine? Top 5 Best Phentermine Alternatives

Is an anorectic drug that was first approved in Europe in 2006 but was withdrawn worldwide in 2008 due to severe psychoactive side effects; It was never approved in the United States.

It works by specific inhibition of the docannabinoid system. It developed from the knowledge that smokers are often, often referred to as “bathers”.

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Sarah Hi I'm Sarah, I like to write anything about health, healthy food and other health tips. Healthy living has become a necessity in this day and age, where the body needs good nutrition. Hopefully my writing can be useful for all.

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