Do Diet Pills Work Nhs – With two-thirds of adults in Britain classified as obese, there is a growing appetite for diet pills that promise rapid weight loss.
Pharmacies and health stores have many weight loss products, many of which are designed to be taken by people who make healthy lifestyle changes.
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Some weight loss products claim to work by suppressing appetite or speeding up metabolism, while others interfere with fat absorption.
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There is currently only one weight loss drug available over the counter in the UK. The drug, orlistat, is usually prescribed to people with a body mass index (BMI) of 28 or higher who have already tried to lose weight by following a diet and exercise plan.
According to the NHS, the drug works by interfering with the way fat is digested and prevents the body from absorbing a third of the fat from food.
There are many types of diet pills that are prescribed in the US. In addition to orlistat, the Food and Drug Administration (FDA) has approved bupropion-naltrexone (Contrave), liraglutide (Saxenda), phentermine-topiramate (Qsymia), and lorcaserin (Belviq) for long-term use.
Lorcaserin, an appetite suppressant, has been hailed by some as the “white pill” in the fight against obesity, but has not been approved by EU regulators.
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A review by NHS doctors and Royal Pharmaceutical Society (RPS) experts found that many weight loss products have little or no published clinical evidence to back up their weight loss claims.
A 2010 study, carried out on behalf of the BBC, looked at five popular products available on the UK high street: Adios, Biosynergy Hoodia Gordonii, LIPObind, Slim Knight and Alli.
It is confirmed by strong research that only Alli helps in weight loss. “Of the four products investigated, there are no randomized clinical trials published to support weight loss,” says Dr Colin Cable of the RPS.
Nutritionist Ruth Kander, who participated in the review, said: “People want to make quick changes in their lives, they want to lose weight very quickly and they don’t want to give up the foods they love.
Orlistat (weight Loss Medicine)
“But it’s not real life and it’s not about clinical practice. And some of these things haven’t had enough research to prove they’re effective.”
According to the NHS, Orlistat is the only anti-obesity drug proven to be safe and effective, but it must be combined with a low-calorie, low-fat diet and regular exercise.
A large Swedish study published in 2004 found that orlistat combined with a healthy diet and exercise helped patients lose about twice as much weight as lifestyle changes.
At the end of the four-year study, researchers found that people who took the drug had less type 2 diabetes.
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Another retrospective study published in 2014 found that adults taking orlistat had a 12-month weight loss that was 7.5lbs (3.4 kg) more than those on placebo.
However, it was only 3.1% of the study’s weight, “which is not very impressive,” argued Joe Leach, an Australian nutritionist, in a Healthline article. Weight also appears to return slowly after the first year of treatment, he said.
In addition, experts warn that Orlistat can cause other unpleasant gastrointestinal problems, including fecal incontinence, shortness of breath, and fatty digestion.
“Although it is an effective drug for weight loss, its side effects include fatty diarrhea, which can cause serious problems,” Dr. David Haslan, chairman of the National Obesity Forum, told Men’s Health.
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Lorcaserin, which has a license for use in the US but not in the EU, has also produced promising results from research conducted by Eisai, the pharmaceutical company that owns the rights to the drug. A September 2018 study found that adults using lorcaserin lost an average of 8.8lb (4kg) over 40 months.
As with other weight loss drugs, the researchers found that people who take this drug do not face an increased risk of heart disease or stroke.
But the NHS says the drug is part of an integrated treatment plan, which also includes changes in diet and exercise, so people “shouldn’t expect to rely on drugs alone” to lose weight.
“Also, the effects related to weight loss were limited,” adds the health website. “At the end of the study most of the people taking the drug were overweight or obese.”
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However, anti-obesity drugs such as orlistat and lorcaserin are safe and can reduce weight modestly compared to placebo when combined with lifestyle changes. There are death concerns related to diet pills containing 2, 4-dinitrophenol (DNP). Increasingly, medical professionals – including pharmacists – are being called upon to play a role in the awareness and prevention of DNP-related complications.
Early on 12 April 2015, 21-year-old student Eloise Parry swallowed eight capsules of ‘DNP’ diet pills. He died less than 12 hours later.
Parry suffered from bulimia and bought 2, 4-dinitrophenol (DNP) pills online from a website run by 31-year-old Bernard Rebelo.
Three years later, a trial at Inner London Crown Court found that Rebelo, of Grimsby Grove, Becton, east London, was making a £200,000 profit by importing the drug from China in 24kg drums and repackaging it into capsules. Every drum. Rebelo admitted he sold Parry’s pills, but insisted he never intended them to be taken by the public, and said the warning on his website reflected that. Rebelo was charged with two counts of murder, although the appeals court rejected it. Technical and is expected to be charged again.
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This case made people aware of the dangers of DNP. In this category it is not allowed to be sold as food or medicine, but it can be sold legally as a fertilizer, wood preservative or paint, and as an insecticide.
In January 2019, Victoria Atkins, Parliamentary Under-Secretary of State for Crime, Safety and Security, wrote to the Advisory Council on the Misuse of Drugs (ACMD) for its views on the appropriate way to implement the DNP.
However, the ACMD concluded that, as there was no conclusive scientific evidence that DNP was psychoactive or that it was misused with the intention of producing psychoactive effects, it was not appropriate to control it under the Misuse of Drugs Act 1971. and toxicologists to find a solution to the toxicity associated with DNP,” said the letter to Atkins.
The Royal Pharmaceutical Society (RPS) is calling for stricter regulations on how these drugs are sold. “Why does it exist in any shape or form?” RPS president Ash Soni asked. “It’s fertilizer. I thought there are other things you can use fertilizer for than DNP. Why can’t it be banned?
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In March 2019, Sony, together with the Society’s Chief Scientist Gino Martini, wrote to the Home Secretary Sajid Javid, urging the government to “ban DNP immediately to reduce the risk of harm and commit to prosecuting those who want to profit from it. Encourage other countries to do the same.
Although over the past two years it has become known that the drug is very dangerous, the message that DNP is deadly is not getting through.
In fact, DNP poisoning cases in the UK reported to the National Poisons Information Service (NPIS) rose in 2018 after three years of decline. In the ten months between January 2018 and September 2018, 17 cases were referred to NPIS, compared to 12 cases reported in all of 2017. And 35% of these 17 cases were fatal – the highest number of deaths. Last five years (see table and picture).
For example, compared to the thousands of cases of paracetamol poisoning, the number of cases of DNP poisoning discussed by NPIS may seem small, but the high risk of death related to DNP and the increase in cases is a concern.
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We saw only three cases of DNP poisoning in the five years from 2007 to 2011, but since 2012 … we have now heard of 115 cases.
“Until 2011, DNP was a very rare poison,” explains Simon Thomas, clinical director at NPIS. “To explain this, we only saw three cases of DNP poisoning in the five years from 2007 to 2011, but since 2012 … we have now heard of 115 cases.”
Simon Thomas, director of clinical practice at the National Poisons Information Service, said that the difference between the dose of DNP required for weight loss and the association with death was small.
In this case, of course, draw part of the picture. By the time NPIS is diagnosed, the patient is symptomatic in the emergency room. The total number of people taking the DNP in the UK is unknown.
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But what is clear is that all healthcare workers, including doctors, should know what DNP is and its risks. “You hope
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