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It took longer than it arrived and they were very helpful and refunded my money .. will buy again from this seller .. 5+ stars – it took longer than it arrived and they were very helpful and refunded my money . Will buy the def again. Buy again from this seller. The pharmacological effects of phentermine are similar to those of amphetamine. The Phentermine resin compound was approved by the FDA in 1959, but is no longer sold in the United States. Phentermine hydrochloride was approved by the FDA in 1973. In the mid-1990s, there was renewed interest in phentermine in combination with fenfluramine, another anorectic, for the treatment of obesity and substance use; however, little scientific data supports this practice. On July 8, 1997, the FDA issued a ‘Dear Healthcare Professional’ letter warning physicians about the development of valvular heart disease and pulmonary hypertension in women taking a combination of fenfluramine and phentermine; Fenfluramine was later withdrawn from the US market in the fall of 1997. The use of phentermine with other anorectic drugs for obesity has not been evaluated and is not recommended. In May 2011, the FDA approved a phentermine hydrochloride tablet (Suprenza) for the treatment of morbid obesity.
There is limited data on the mechanism of action of this drug in the reference literature. Phentermine is an analog of methamphetamine. Like amphetamine, phentermine increases the release of norepinephrine and dopamine from nerve terminals and inhibits their reuptake. Therefore, phentermine is classified as an indirect sympathomimetic. 2 Other effects include a weak ability to increase serotonin levels in a dose-dependent manner, although the effect on serotonin is less strong than that of methamphetamine. Clinical effects including 3 CNS stimulation and increased blood pressure. Print is believed to result in suppression of appetite by direct stimulation of the satiety center in the hypothalamic and limbic regions.
Tolerance to the anorexic effects of phentermine usually develops within a few weeks of starting treatment. The mechanism of tolerance appears to be pharmacodynamic in nature; Higher doses of phentermine are needed to produce the same response. When tolerance to anorexic effects develops, it is usually recommended to discontinue phentermine rather than increase the dose.
Phentermine is administered orally. The rate and extent of exposure to phentermine in the fasting state are similar regardless of the oral form administered
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There are limited data on the pharmacokinetics of phentermine. Phentermine is mainly excreted by the kidney. The elimination half-life is 19–24 hours and is affected by urine pH. Since the pKa of phentermine is 9.84, the elimination half-life is reduced to approximately 7–8 hours under acidic urine conditions.
Oral route: Following oral administration, maximum absorption of phentermine occurs from the small intestine. The duration of action is approximately 4 hours after using the 30 mg capsule or 37.5 mg tablet and 12-14 hours after using the 8 mg capsule or tablet.
Phentermine oral disintegrating tablet (ODT) reaches peak levels (Cmax) after 3-4.4 hours after administration. Drinking water before ODT ingestion does not affect AUC. Despite reductions in Cmax (approximately 5%) and AUC (approximately 12%) when phentermine ODT was administered after a high-fat/high-calorie breakfast, phentermine ODT may be administered with or without food. When the ODT was swallowed without prior parturition, Cmax and AUC decreased by approximately 7% and 8%, respectively.
Renal impairment: Use with caution in patients with renal impairment. The cumulative urinary excretion of phentermine is 62–85% under conditions of uncontrolled urinary pH, and may be expected to increase in patients with renal impairment.1
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According to the formulation of phentermine capsules and tablets, its products are contraindicated in patients with heart disease, advanced arteriosclerosis, moderate to severe hypertension, states of anxiety or glaucoma. Diseases including coronary artery disease, stroke, heart arrhythmias, heart failure and uncontrolled high blood pressure. The safety and efficacy of combination therapy with phentermine and any other weight loss drugs, including selective serotonin reuptake inhibitors (eg, fluoxetine, sertraline, fluvoxamine, paroxetine) have not been established. Therefore, co-administration of these drugs for weight loss is not recommended. Additionally, primary pulmonary hypertension (PPH) has been reported in patients taking fenfluramine or the combination of phentermine with dexfenfluramine. The possibility of an association between the use of phentermine and PPH or valvular heart disease alone cannot be ruled out. The initial symptom of PPH is usually shortness of breath. Other early symptoms include: angina pectoris, fainting, or swelling of the lower leg. Patients should be advised to immediately report any decline in exercise tolerance. Treatment should be discontinued in patients who develop new and unexplained symptoms of dyspnoea, angina pectoris, syncope, or edema of the lower limbs.
Because phentermine is a sympathomimetic agent, it is contraindicated in patients with hyperthyroidism. It should also be used with caution in patients with thyroid disease.
Phentermine is contraindicated for use during or within 14 days following MAOI therapy or use of other drugs with MAO inhibitory activity. Monoamine oxidase inhibitors (MAOIs), or drugs that have MAO inhibitory activity such as furazolidone or procarbazine, may prolong and potentiate the cardiac stimulation and vasopressor effects of phentermine.
Phentermine is contraindicated in patients with an excited state. Enhances these effects or causes adverse drug reactions. 4 Symptoms of chronic intoxication include insomnia, irritability, personality changes, and psychotic symptoms that may be clinically indistinguishable from other psychiatric disorders, such as schizophrenia. , Phentermine may worsen certain mental conditions, such as in patients who display excessively restless or agitated behavior, including psychosis, mania, or severe anxiety.
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Use of phentermine may cause symptoms of dizziness, mask symptoms of fatigue or the need for rest, or may decrease the patient’s ability to participate in activities requiring mental alertness. Advise patients to exercise caution when driving or operating machinery, or performing other tasks requiring mental alertness, until they know how the drug will affect their mental and/or motor performance. In general, ethanol consumption can enhance these effects or cause adverse drug reactions. Advise patients to avoid alcohol while taking phentermine.
Use phentermine with caution in patients with diabetes. Insulin or other antidiabetic medication requirements may be changed in these patients when phentermine is used during weight loss and because of a change in dietary regimen. Patients should monitor their blood sugar regularly and follow health care recommendations
Not recommended in patients with a history of anorexia nervosa or other eating disorders. The use of phentermine is contraindicated in patients with a known history of drug or substance abuse. Phentermine is chemically and pharmacologically related to the widely abused amphetamines. The potential for phentermine abuse should be taken into account when considering the desirability of including the drug as part of a weight loss program. The smallest appropriate dose should be administered or dispensed at once to limit the potential for drug overdose
Phentermine products are currently classified as an FDA pregnancy risk category X, as are many anorexants used for weight loss, and are contraindicated during pregnancy. 56 The safe use of phentermine during pregnancy has not been established; There are no known indications for the use of phentermine during pregnancy. Phentermine should not be taken by pregnant women or women who may become pregnant unless, in the opinion of the physician, the potential benefits outweigh the potential risks. 6
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Abrupt discontinuation of phentermine following prolonged high doses may result in severe mental depression or severe fatigue; Sleep EEG changes have also been noted. Gradual withdrawal from treatment is recommended. If immediate discontinuation is medically necessary, careful monitoring and symptomatic management are essential.4
Phentermine is contraindicated during breastfeeding. 5 It is not known whether phentermine and its metabolites are excreted in breast milk; However, because of the potential for serious negative effects in nursing
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